Is less of physical strenght and more of overall skill, if this guy was infeed a scientist, then combat was secondary in his life, meaning a proficient Predator that trains for warfare could do much more when compared to him.
Assassin could fit in this description, but he was a living hack, so his feats seems less impressive when he is bulletproof. So I considere Wolf the closest of this aspect, and he held himself pretty good against the Predalien.
I heard there was gonna have a sequence showing how they captured him, so if they developted weapons to capture him based on P2, we will never know. Shame they cut it, it would had been better then the kid subplot or the loonies scenes.
I would say he would have a solid chance, his downfall was underestimating his opponent.