I think in general actual melee combat with a predator should be a death sentence. A lot of people point to the scene where the Yakuza killed the Tracker predator as how a skilled human could fair against a yautja. The more I think about it, unless that predator was extremely weak it shouldn’t have gone down so easily.
City Hunter survived being blasted with a shotgun, having an arm chopped off, falling from a building and almost being frozen before he lost to Glover and one of his own weapons. I know the filmmakers behind Predators wanted to show what we missed in the Billy vs Jungle Hunter melee battle from the first movie. But really they kind of dishonored Billy and the yautja. Billy was a bada$$ and he lasted like 5 seconds against the Jungle Hunter hand to hand, but the Yakuza manages to kill a pred? Meh.
As for the game the parry is ridiculous at times but I get why it’s there.